Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus.
Influenza Other Respir Viruses
; 14(3): 353-357, 2020 05.
Article
em En
| MEDLINE
| ID: mdl-31994309
ABSTRACT
Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is a characteristic of BXM. There may be a possibility that drug carryover effects have impacts on the observed antiviral effects due to the poor correlation that was observed between viral titer reduction and alleviation of influenza symptoms. Here, we report possible carryover effects of baloxavir acid (BXA), an active form of BXM, on infectious titer testing. Our findings indicate that there is little impact of BXA carryover on the infectious titer testing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Orthomyxoviridae
/
Faringe
/
Piridonas
/
Triazinas
/
Morfolinas
/
Nasofaringe
/
Dibenzotiepinas
/
Influenza Humana
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Influenza Other Respir Viruses
Ano de publicação:
2020
Tipo de documento:
Article