Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury through inhibiting the mincle maintained macrophage inflammation.

Hui, Diao; Rui-Zhi, Tan; Jian-Chun, Li; Xia, Zhong; Dan, Wen; Jun-Ming, Fan; Li, Wang

Hui, Diao; Rui-Zhi, Tan; Jian-Chun, Li; Xia, Zhong; Dan, Wen; Jun-Ming, Fan; Li, Wang.

Afiliação

Hui D; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China; Department of Nephrology, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Rui-Zhi T; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Jian-Chun L; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Xia Z; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Dan W; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China; Department of Nephrology, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Jun-Ming F; Chengdu Medical College, Chengdu, 610000, Sichuan, China; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China.
Li W; Research Center of Combine Traditional Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, China. Electronic address: wangli120@swmu.edu.cn.

J Ethnopharmacol ; 252: 112637, 2020 Apr 24.

Article em En | MEDLINE | ID: mdl-32004631

Assuntos

Injúria Renal Aguda/tratamento farmacológico; Anti-Inflamatórios/uso terapêutico; Lectinas Tipo C/antagonistas & inibidores; Proteínas de Membrana/antagonistas & inibidores; Substâncias Protetoras/uso terapêutico; Injúria Renal Aguda/induzido quimicamente; Injúria Renal Aguda/metabolismo; Injúria Renal Aguda/patologia; Animais; Anti-Inflamatórios/farmacologia; Antineoplásicos; Células Cultivadas; Cisplatino; Citocinas/genética; Rim/efeitos dos fármacos; Rim/patologia; Lectinas Tipo C/genética; Lectinas Tipo C/metabolismo; Lipopolissacarídeos; Macrófagos/efeitos dos fármacos; Macrófagos/imunologia; Masculino; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos Endogâmicos C57BL; NF-kappa B/metabolismo; Substâncias Protetoras/farmacologia; Transdução de Sinais/efeitos dos fármacos; Quinase Syk/metabolismo

Palavras-chave

AKI; Astragalus propinquus schischkin and panax notoginseng compound; BMDM; Mincle; NF-κB

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Substâncias Protetoras / Lectinas Tipo C / Injúria Renal Aguda / Proteínas de Membrana / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2020 Tipo de documento: Article

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