BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence.

Mendez-Dorantes, Carlos; Tsai, L Jillianne; Jahanshir, Eva; Lopezcolorado, Felicia Wednesday; Stark, Jeremy M

Mendez-Dorantes, Carlos; Tsai, L Jillianne; Jahanshir, Eva; Lopezcolorado, Felicia Wednesday; Stark, Jeremy M.

Afiliação

Mendez-Dorantes C; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Tsai LJ; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Jahanshir E; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Lopezcolorado FW; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Stark JM; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address: jstark@coh.org.

Cell Rep ; 30(5): 1342-1357.e4, 2020 02 04.

Article em En | MEDLINE | ID: mdl-32023454

Assuntos

Quebras de DNA de Cadeia Dupla; Deleção de Genes; RecQ Helicases/metabolismo; Sequências Repetitivas de Ácido Nucleico/genética; Animais; Proteína BRCA2/metabolismo; Linhagem Celular; DNA Helicases/metabolismo; Enzimas Reparadoras do DNA/metabolismo; Endodesoxirribonucleases/metabolismo; Epistasia Genética; Exodesoxirribonucleases/metabolismo; Camundongos; Enzimas Multifuncionais/metabolismo; Proteína 2 Homóloga a MutS/metabolismo; Proteína Rad52 de Recombinação e Reparo de DNA/metabolismo

Palavras-chave

BLM; DNA double-strand break repair; DNA2; EXO1; Heteroduplex Rejection; Homologous recombination; MSH2; RAD52; Single-Strand Annealing; repeat-mediated deletions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sequências Repetitivas de Ácido Nucleico / Deleção de Genes / RecQ Helicases / Quebras de DNA de Cadeia Dupla Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2020 Tipo de documento: Article

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