TLR5 agonist entolimod reduces the adverse toxicity of TNF while preserving its antitumor effects.

Haderski, Gary J; Kandar, Bojidar M; Brackett, Craig M; Toshkov, Ilia M; Johnson, Christopher P; Paszkiewicz, Geraldine M; Natarajan, Venkatesh; Gleiberman, Anatoli S; Gudkov, Andrei V; Burdelya, Lyudmila G

Haderski, Gary J; Kandar, Bojidar M; Brackett, Craig M; Toshkov, Ilia M; Johnson, Christopher P; Paszkiewicz, Geraldine M; Natarajan, Venkatesh; Gleiberman, Anatoli S; Gudkov, Andrei V; Burdelya, Lyudmila G.

Afiliação

Haderski GJ; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Kandar BM; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Brackett CM; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Toshkov IM; Genome Protection, Inc., Buffalo, New York, United States of America.
Johnson CP; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Paszkiewicz GM; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Natarajan V; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Gleiberman AS; Genome Protection, Inc., Buffalo, New York, United States of America.
Gudkov AV; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.
Burdelya LG; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States America.

PLoS One ; 15(2): e0227940, 2020.

Article em En | MEDLINE | ID: mdl-32027657

Assuntos

Antineoplásicos/farmacologia; Peptídeos/farmacologia; Receptor 5 Toll-Like/agonistas; Fator de Necrose Tumoral alfa/toxicidade; Animais; Linhagem Celular Tumoral; Células Cultivadas; Galactosamina; Hematopoese/efeitos dos fármacos; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Lipopolissacarídeos/toxicidade; Fígado/efeitos dos fármacos; Fígado/patologia; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Modelos Biológicos; NF-kappa B/metabolismo; Substâncias Protetoras/farmacologia; Análise de Sobrevida; Receptor 5 Toll-Like/metabolismo; Fator de Necrose Tumoral alfa/sangue; Regulação para Cima/efeitos dos fármacos; Regulação para Cima/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Fator de Necrose Tumoral alfa / Receptor 5 Toll-Like / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Ano de publicação: 2020 Tipo de documento: Article

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