Association of glucose tolerance status with pancreatic ß- and α-cell mass in community-based autopsy samples of Japanese individuals: The Hisayama Study.
J Diabetes Investig
; 11(5): 1197-1206, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32031300
ABSTRACT
AIMS/INTRODUCTION:
Changes in histologically quantified ß- and α-cell mass during the development of glucose intolerance have not been fully elucidated. The aim of the present study was to explore differences in ß- and α-cell mass according to the glucose tolerance status. MATERIALS ANDMETHODS:
Autopsy samples from a total of 103 individuals (40 with normal glucose tolerance, 31 with prediabetes and 32 with type 2 diabetes mellitus) who underwent a 75-g oral glucose tolerance test within 5 years before death were selected from 643 community-based autopsy samples collected from 2002 to 2016. Fractional ß-cell area (BCA) and α-cell area were quantified with Image Pro Plus software. Associations of BCA and α-cell area with glucose tolerance status were assessed using a linear regression analysis, and Spearman's correlation coefficients between glycemic markers and ß-cell function were estimated.RESULTS:
The mean values of BCA decreased significantly with worsening glucose tolerance status (mean ± standard error 1.85 ± 0.10% in normal glucose tolerance, 1.59 ± 0.11% in prediabetes and 1.17 ± 0.11% in type 2 diabetes mellitus, P for trend < 0.001), whereas there was no significant association between α-cell area and glucose tolerance status. BCA was inversely correlated with fasting and 2-h plasma glucose levels during oral glucose tolerance test and glycated hemoglobin measurement, and positively correlated with disposition index (all P < 0.01).CONCLUSIONS:
ß-Cell mass decreased significantly with worsening glucose tolerance, from the stage of prediabetes, in the Japanese population. Prevention of declining ß-cell mass before the onset of glucose intolerance is important to reduce the burden of type 2 diabetes mellitus.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
/
Intolerância à Glucose
/
Diabetes Mellitus Tipo 2
/
Células Secretoras de Glucagon
/
Células Secretoras de Insulina
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Diabetes Investig
Ano de publicação:
2020
Tipo de documento:
Article