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Calmodulin-Binding Proteins in Muscle: A Minireview on Nuclear Receptor Interacting Protein, Neurogranin, and Growth-Associated Protein 43.
Moradi, Fereshteh; Copeland, Emily N; Baranowski, Ryan W; Scholey, Aiden E; Stuart, Jeffrey A; Fajardo, Val A.
Afiliação
  • Moradi F; Department of Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Copeland EN; Centre for Neuroscience, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Baranowski RW; Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Scholey AE; Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Stuart JA; Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Fajardo VA; Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada.
Int J Mol Sci ; 21(3)2020 Feb 04.
Article em En | MEDLINE | ID: mdl-32033037
ABSTRACT
Calmodulin (CaM) is an important Ca2+-sensing protein with numerous downstream targets that are either CaM-dependant or CaM-regulated. In muscle, CaM-dependent proteins, which are critical regulators of dynamic Ca2+ handling and contractility, include calcineurin (CaN), CaM-dependant kinase II (CaMKII), ryanodine receptor (RyR), and dihydropyridine receptor (DHPR). CaM-regulated targets include genes associated with oxidative metabolism, muscle plasticity, and repair. Despite its importance in muscle, the regulation of CaM-particularly its availability to bind to and activate downstream targets-is an emerging area of research. In this minireview, we discuss recent studies revealing the importance of small IQ motif proteins that bind to CaM to either facilitate (nuclear receptor interacting protein; NRIP) its activation of downstream targets, or sequester (neurogranin, Ng; and growth-associated protein 43, GAP43) CaM away from their downstream targets. Specifically, we discuss recent studies that have begun uncovering the physiological roles of NRIP, Ng, and GAP43 in skeletal and cardiac muscle, thereby highlighting the importance of endogenously expressed CaM-binding proteins and their regulation of CaM in muscle.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calmodulina / Proteína GAP-43 / Sinalização do Cálcio / Neurogranina / Proteína 1 de Interação com Receptor Nuclear Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calmodulina / Proteína GAP-43 / Sinalização do Cálcio / Neurogranina / Proteína 1 de Interação com Receptor Nuclear Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article