Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.

Shao, Yu-Ying; Yin, Yong; Lian, Bao-Ping; Leng, Jia-Fu; Xia, Yuan-Zheng; Kong, Ling-Yi

Shao, Yu-Ying; Yin, Yong; Lian, Bao-Ping; Leng, Jia-Fu; Xia, Yuan-Zheng; Kong, Ling-Yi.

Afiliação

Shao YY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR China.
Yin Y; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR China.
Lian BP; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR China.
Leng JF; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR China.
Xia YZ; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR China.
Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, PR China. Electronic address: cpu_lykong

Eur J Med Chem ; 190: 112105, 2020 Mar 15.

Article em En | MEDLINE | ID: mdl-32035399

Assuntos

Benzofuranos/farmacologia; Naftoquinonas/farmacologia; Moduladores de Tubulina/farmacologia; Tubulina (Proteína)/metabolismo; Antineoplásicos/síntese química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Antineoplásicos/toxicidade; Apoptose/efeitos dos fármacos; Benzofuranos/síntese química; Benzofuranos/metabolismo; Benzofuranos/toxicidade; Sítios de Ligação; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana; Humanos; Simulação de Acoplamento Molecular; Naftoquinonas/síntese química; Naftoquinonas/metabolismo; Naftoquinonas/toxicidade; Ligação Proteica; Moduladores de Tubulina/síntese química; Moduladores de Tubulina/metabolismo; Moduladores de Tubulina/toxicidade

Palavras-chave

Colchicine binding site; Microtubule; Shikonin-benzo[b]furan derivatives; Tubulin polymerization inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tubulina (Proteína) / Benzofuranos / Naftoquinonas / Moduladores de Tubulina Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article

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