Does Hormone Replacement Therapy Impact the Prognosis in Endometrial Cancer Survivors? A Systematic Review.
Oncology
; 98(4): 195-201, 2020.
Article
em En
| MEDLINE
| ID: mdl-32036368
ABSTRACT
PURPOSE:
The objective of this study was to evaluate the impact of hormone replacement therapy (HRT) on the prognosis in endometrial cancer (EC) survivors.METHODS:
The research was conducted using the following electronic databases MEDLINE (PubMed), Web of Science, ClinicalTrial.gov, and Cochrane Library. We performed a review of studies published from January 1986 to January 2019. We selected studies that included EC patients submitted to surgery with curative intent and postoperative use of HRT.RESULT:
Seven of 1,332 abstracts considered were eligible 4 retrospective series, 1 prospective study, 1 randomized controlled trial, and 1 population study. Globally in the observed studies there was not a significant increase in the recurrence rate, measured by the relative risk, in the EC survivors using HRT compared with the controls in tumour stages I and II. The bias was that HRT was prescribed only to low-risk patients, who were young and had a low stage of disease.CONCLUSION:
This systematic review shows that HRT use had no negative effect on prognosis in EC survivors in tumour stages I and II.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Endométrio
/
Terapia de Reposição Hormonal
/
Sobreviventes de Câncer
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Revista:
Oncology
Ano de publicação:
2020
Tipo de documento:
Article