New therapeutic perspectives for IgA nephropathy in children.
Pediatr Nephrol
; 36(3): 497-506, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-32040630
ABSTRACT
Childhood IgA nephropathy (cIgAN) differs from the adult by having an abrupt clinical onset, often presenting as an acute attack that can progress to a chronic phase. No treatment guidelines have been established for the treatment of cIgAN. Given the severity of acute attack in children, and the number of life-years at stake, pediatricians prescribe immunosuppression in addition to renin-angiotensin system blockade. Non-specific immunosuppressors, such as corticosteroids, have systemic toxic effects, and given recent therapeutic advances in adult glomerulonephritis, new tailored strategies should be expected for children. The mucosal immune system has been highlighted as a key player in IgAN pathogenesis, and several biomarkers have been identified with a direct role in pathogenesis. In this review, we discuss current studies of conventional and novel therapeutic approaches for cIgAN.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glomerulonefrite por IGA
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Aspecto:
Patient_preference
Limite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Nephrol
Ano de publicação:
2021
Tipo de documento:
Article