Diagnostic Performance of 18F-FDG PET or PET/CT for Detection of Post-Transplant Lymphoproliferative Disorder: A Systematic Review and a Bivariate Meta-Analysis.
Diagnostics (Basel)
; 10(2)2020 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-32059610
ABSTRACT
BACKGROUND:
Some studies evaluated the diagnostic performance of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) for the detection of post-transplant lymphoproliferative disorder (PTLD). As there is no clear consensus about the diagnostic accuracy of these imaging methods, we performed a meta-analysis on this topic.METHODS:
A comprehensive computer literature search of PubMed, Embase, and Cochrane library databases through December 2019 was performed. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-), and diagnostic odds ratio (DOR) of 18F-FDG PET or PET/CT for detection of PTLD were calculated.RESULTS:
Five studies reporting data on the diagnostic performance of 18F-FDG PET or PET/CT in 336 transplant recipients were included in the systematic review and bivariate meta-analysis. Pooled sensitivity and specificity for detection of PTLD were 89.7% (95% confidence interval (95%CI) 84.6-93.2%) and 90.9% (95%CI 85.9-94.3%), respectively. Pooled LR+, LR-, and DOR were 8.9 (95%CI 5.7-14), 0.13 (95%CI 0.08-0.2), and 70.4 (95%CI 35.4-140), respectively. A significant heterogeneity among studies was not detected.CONCLUSIONS:
Despite limited literature data, 18F-FDG PET or PET/CT demonstrated good diagnostic performance for the detection of PTLD, but large prospective studies are needed to strengthen these findings.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Systematic_reviews
Idioma:
En
Revista:
Diagnostics (Basel)
Ano de publicação:
2020
Tipo de documento:
Article