TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease.

Du, Yehong; Fu, Min; Huang, Zhilin; Tian, Xin; Li, Junjie; Pang, Yayan; Song, Weihong; Tian Wang, Yu; Dong, Zhifang

Du, Yehong; Fu, Min; Huang, Zhilin; Tian, Xin; Li, Junjie; Pang, Yayan; Song, Weihong; Tian Wang, Yu; Dong, Zhifang.

Afiliação

Du Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o
Fu M; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o
Huang Z; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o
Tian X; Department of Neurology, Chongqing Key Laboratory of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li J; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o
Pang Y; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o
Song W; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o
Tian Wang Y; Department of Psychiatry, Townsend Family Laboratories, University of British Columbia, Vancouver, BC, Canada.
Dong Z; Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory o

Aging Cell ; 19(3): e13113, 2020 03.

Article em En | MEDLINE | ID: mdl-32061032

Assuntos

Doença de Alzheimer/metabolismo; Disfunção Cognitiva/metabolismo; Endocitose/genética; Potenciação de Longa Duração/genética; Receptores de AMPA/metabolismo; Canais de Cátion TRPV/metabolismo; Doença de Alzheimer/genética; Peptídeos beta-Amiloides/metabolismo; Animais; Região CA1 Hipocampal/metabolismo; Disfunção Cognitiva/genética; Modelos Animais de Doenças; Aprendizagem em Labirinto; Memória; Camundongos; Camundongos Transgênicos; Transdução de Sinais/efeitos dos fármacos; Aprendizagem Espacial; Sinapses/metabolismo; Canais de Cátion TRPV/genética

Palavras-chave

AMPA receptor endocytosis; Alzheimer's disease; TRPV1; capsaicin; learning and memory; long-term potentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de AMPA / Potenciação de Longa Duração / Endocitose / Canais de Cátion TRPV / Doença de Alzheimer / Disfunção Cognitiva Limite: Animals Idioma: En Revista: Aging Cell Ano de publicação: 2020 Tipo de documento: Article

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