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EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma.
Struve, Nina; Binder, Zev A; Stead, Lucy F; Brend, Tim; Bagley, Stephen J; Faulkner, Claire; Ott, Leonie; Müller-Goebel, Justus; Weik, Anna-Sophie; Hoffer, Konstantin; Krug, Leonie; Rieckmann, Thorsten; Bußmann, Lara; Henze, Marvin; Morrissette, Jennifer J D; Kurian, Kathreena M; Schüller, Ulrich; Petersen, Cordula; Rothkamm, Kai; O Rourke, Donald M; Short, Susan C; Kriegs, Malte.
Afiliação
  • Struve N; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ni.struve@uke.de.
  • Binder ZA; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Stead LF; Leeds Institute of Medical Research at St James's, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, UK.
  • Brend T; Leeds Institute of Medical Research at St James's, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, UK.
  • Bagley SJ; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Faulkner C; Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK.
  • Ott L; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Müller-Goebel J; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Weik AS; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hoffer K; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Krug L; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Rieckmann T; Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
  • Bußmann L; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Henze M; Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
  • Morrissette JJD; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kurian KM; Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
  • Schüller U; Laboratory of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum - University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Petersen C; Department of Radiotherapy and Radiooncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Rothkamm K; Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
  • O Rourke DM; Bristol Brain Tumour Research Centre, University of Bristol, Bristol, UK.
  • Short SC; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
  • Kriegs M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Oncogene ; 39(15): 3041-3055, 2020 04.
Article em En | MEDLINE | ID: mdl-32066879

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Metilases de Modificação do DNA / Glioblastoma / Resistencia a Medicamentos Antineoplásicos / Proteínas Supressoras de Tumor / Enzimas Reparadoras do DNA / Temozolomida Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncogene Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Metilases de Modificação do DNA / Glioblastoma / Resistencia a Medicamentos Antineoplásicos / Proteínas Supressoras de Tumor / Enzimas Reparadoras do DNA / Temozolomida Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncogene Ano de publicação: 2020 Tipo de documento: Article