Synthesis and Biological Evaluation of New Naphthoquinones Derivatives.
Curr Org Synth
; 17(3): 224-229, 2020.
Article
em En
| MEDLINE
| ID: mdl-32091341
ABSTRACT
New substituted 1,4-naphthoquinones have been prepared in good overall yields through the naphthol route. The cytotoxicity of these compounds was tested in vitro on MCF-7 breast tumor cells. The most active compound 14 displayed an IC50 of 15µM. OBJECTIVE:
To investigate the cytotoxicity of new naphthoquinones derivatives on MCF-7 cells.METHODS:
Synthesis of new naphtoquinones derivatives and in vitro evaluation of their cytotoxicity on MCF-7 cells (rezasurin cell-based assay).RESULTS:
Starting from Ethyl 4-hydroxy-6,7-dimethoxy-2-naphthoate, four naphthoquinones were prepared and exhibited substantial cytotoxicity against MCF-7 cells.CONCLUSION:
Preliminary studies of the structure-activity relationship have shown the influence of the structural parameters and, in particular, the nature of the naphthoquinone side chain.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Naftoquinonas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Curr Org Synth
Ano de publicação:
2020
Tipo de documento:
Article