Synthesis of a meso-Oxa-Diaminopimelic Acid Containing Peptidoglycan Pentapeptide and Coupling to the GlcNAc-anhydro-MurNAc Disaccharide.
Org Lett
; 22(6): 2313-2317, 2020 03 20.
Article
em En
| MEDLINE
| ID: mdl-32133861
ABSTRACT
The syntheses of peptidoglycan (PG)-derived peptides containing meso-diaminopimelic acid (meso-Dap) are typically quite lengthy due to the need to prepare orthogonally protected meso-Dap. In this work, the preparation of the PG pentapeptide containing the isosteric analog meso-oxa-Dap is described. The synthesis relies on the ring opening of a peptide embedded aziridine via the attack of a serine residue. The pentapeptide was attached to a GlcNAc-anhydro-MurNAc disaccharide, to produce a putative substrate for the AmpG pore protein.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Acetilglucosamina
/
Peptidoglicano
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Ácido Diaminopimélico
/
Dissacarídeos
/
Ácidos Murâmicos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2020
Tipo de documento:
Article