Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells.

Luis, Tiago C; Lawson, Hannah; Kranc, Kamil R

Luis, Tiago C; Lawson, Hannah; Kranc, Kamil R.

Afiliação

Luis TC; Haematopoietic Stem Cell Niche Laboratory, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK. Electronic address: t.luis@imperial.ac.uk.
Lawson H; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Kranc KR; Laboratory of Haematopoietic Stem Cell & Leukaemia Biology, Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address: kamil.kranc@qmul.ac.uk.

Cell Stem Cell ; 26(3): 299-301, 2020 03 05.

Article em En | MEDLINE | ID: mdl-32142657

ABSTRACT

ABSTRACT

Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity. In this issue of Cell Stem Cell, Hinge et al. (2020) and Liang et al. (2020) demonstrate that HSCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and maintaining healthy punctate mitochondria with low metabolic activity.

Assuntos

Células-Tronco Hematopoéticas; Dinâmica Mitocondrial; Divisão Celular; Autorrenovação Celular; Mitocôndrias

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Dinâmica Mitocondrial Idioma: En Revista: Cell Stem Cell Ano de publicação: 2020 Tipo de documento: Article

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