Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling.

Hu, Bowen; Yang, Renjun; Cheng, Zhanwen; Liang, Shaojun; Liang, Shengxian; Yin, Nuoya; Faiola, Francesco

Hu, Bowen; Yang, Renjun; Cheng, Zhanwen; Liang, Shaojun; Liang, Shengxian; Yin, Nuoya; Faiola, Francesco.

Afiliação

Hu B; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yang R; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Cheng Z; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Liang S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Liang S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.
Yin N; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: nyyin@r
Faiola F; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: faiola@

J Hazard Mater ; 393: 122440, 2020 07 05.

Article em En | MEDLINE | ID: mdl-32151936

Assuntos

Fatores de Crescimento de Fibroblastos/metabolismo; Células-Tronco Embrionárias Humanas/efeitos dos fármacos; Nanopartículas Metálicas/toxicidade; Nitrato de Prata/toxicidade; Prata/toxicidade; Diferenciação Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Ectoderma/efeitos dos fármacos; Proteínas do Olho/metabolismo; Proteínas de Homeodomínio/metabolismo; Células-Tronco Embrionárias Humanas/metabolismo; Humanos; Proteínas do Tecido Nervoso/metabolismo; Crista Neural/efeitos dos fármacos; Fator de Transcrição PAX6/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos; Proteína Homeobox SIX3

Palavras-chave

Cranial placode; Developmental toxicity; Ectoderm; Silver nanoparticles (AgNPs); Stem cell toxicology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Nitrato de Prata / Nanopartículas Metálicas / Fatores de Crescimento de Fibroblastos / Células-Tronco Embrionárias Humanas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Hazard Mater Ano de publicação: 2020 Tipo de documento: Article

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