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Technical Note: Integrating an open source Monte Carlo code "MCsquare" for clinical use in intensity-modulated proton therapy.
Deng, Wei; Younkin, James E; Souris, Kevin; Huang, Sheng; Augustine, Kurt; Fatyga, Mirek; Ding, Xiaoning; Cohilis, Marie; Bues, Martin; Shan, Jie; Stoker, Joshua; Lin, Liyong; Shen, Jiajian; Liu, Wei.
Afiliação
  • Deng W; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Younkin JE; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Souris K; Center for Molecular Imaging and Experimental Radiotherapy, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, 1200, Brussels, Belgium.
  • Huang S; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Augustine K; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Fatyga M; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Ding X; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Cohilis M; Center for Molecular Imaging and Experimental Radiotherapy, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, 1200, Brussels, Belgium.
  • Bues M; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Shan J; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Stoker J; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Lin L; Emory Proton Therapy Center, Emory University, Atlanta, GA, USA.
  • Shen J; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
  • Liu W; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, 85054, USA.
Med Phys ; 47(6): 2558-2574, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32153029
PURPOSE: To commission an open source Monte Carlo (MC) dose engine, "MCsquare" for a synchrotron-based proton machine, integrate it into our in-house C++-based I/O user interface and our web-based software platform, expand its functionalities, and improve calculation efficiency for intensity-modulated proton therapy (IMPT). METHODS: We commissioned MCsquare using a double Gaussian beam model based on in-air lateral profiles, integrated depth dose of 97 beam energies, and measurements of various spread-out Bragg peaks (SOBPs). Then we integrated MCsquare into our C++-based dose calculation code and web-based second check platform "DOSeCHECK." We validated the commissioned MCsquare based on 12 different patient geometries and compared the dose calculation with a well-benchmarked GPU-accelerated MC (gMC) dose engine. We further improved the MCsquare efficiency by employing the computed tomography (CT) resampling approach. We also expanded its functionality by adding a linear energy transfer (LET)-related model-dependent biological dose calculation. RESULTS: Differences between MCsquare calculations and SOBP measurements were <2.5% (<1.5% for ~85% of measurements) in water. The dose distributions calculated using MCsquare agreed well with the results calculated using gMC in patient geometries. The average 3D gamma analysis (2%/2 mm) passing rates comparing MCsquare and gMC calculations in the 12 patient geometries were 98.0 ± 1.0%. The computation time to calculate one IMPT plan in patients' geometries using an inexpensive CPU workstation (Intel Xeon E5-2680 2.50 GHz) was 2.3 ± 1.8 min after the variable resolution technique was adopted. All calculations except for one craniospinal patient were finished within 3.5 min. CONCLUSIONS: MCsquare was successfully commissioned for a synchrotron-based proton beam therapy delivery system and integrated into our web-based second check platform. After adopting CT resampling and implementing LET model-dependent biological dose calculation capabilities, MCsquare will be sufficiently efficient and powerful to achieve Monte Carlo-based and LET-guided robust optimization in IMPT, which will be done in the future studies.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Radioterapia de Intensidade Modulada / Terapia com Prótons Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Humans Idioma: En Revista: Med Phys Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Radioterapia de Intensidade Modulada / Terapia com Prótons Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Humans Idioma: En Revista: Med Phys Ano de publicação: 2020 Tipo de documento: Article