Experimental evidence for the involvement of F0/F1 ATPase and subsequent P2Y12 receptor activation in prothymosin alpha-induced protection of retinal ischemic damage.
J Pharmacol Sci
; 143(2): 127-131, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32156464
ABSTRACT
The inhibition of retinal ischemia-induced damage by post-ischemic prothymosin alpha (ProTα) was not affected in toll-like receptor 4 knockout (TLR4-/-) mice but blocked by the pretreatment with antibody against F0/F1 ATPase α- or ß-subunit, novel candidate for ProTα-receptor. In addition to the previous observation of ProTα-induced ATP release from cells, the present study showed a ProTα-induced enhancement of ATP hydrolysis activity of recombinant ATP5A1/5B complex. As the protection of retinal function by post-ischemic ProTα was abolished by anti-P2Y12 antibody, the activation of F0/F1 ATPase and subsequent P2Y12 receptor system may play roles in beneficial actions by post-ischemic ProTα.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
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Retina
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Timosina
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ATPases Translocadoras de Prótons
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Receptores Purinérgicos P2Y12
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Isquemia
Limite:
Animals
Idioma:
En
Revista:
J Pharmacol Sci
Ano de publicação:
2020
Tipo de documento:
Article