Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progression.

Xie, Zhiqi; Ikegami, Tamami; Ago, Yukio; Okada, Naoki; Tachibana, Masashi

Xie, Zhiqi; Ikegami, Tamami; Ago, Yukio; Okada, Naoki; Tachibana, Masashi.

Afiliação

Xie Z; Project for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Ikegami T; Project for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Ago Y; Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Okada N; Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan.
Tachibana M; Project for Vaccine and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

Oncoimmunology ; 9(1): 1734268, 2020.

Article em En | MEDLINE | ID: mdl-32158627

Assuntos

Células Supressoras Mieloides; Neoplasias; Animais; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Receptores CCR2; Microambiente Tumoral; Ácido Valproico/farmacologia

Palavras-chave

CCR2; Myeloid-derived suppressor cell; anti PD-1 antibody; combination therapy; valproic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Supressoras Mieloides / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncoimmunology Ano de publicação: 2020 Tipo de documento: Article

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