A framework for understanding Kawasaki disease pathogenesis.
Clin Immunol
; 214: 108385, 2020 05.
Article
em En
| MEDLINE
| ID: mdl-32173601
ABSTRACT
Kawasaki disease (KD) is a common vasculitis of childhood, typically affecting children under the age of five. Despite many aspects of its presentation that bear resemblence to acute infection, no causative infectious agent has been identified despite years of intense scrutiny. Unlike most infections, however, there are significant differences in racial predilection that suggest a strong genetic influence. The inflammatory response in KD specifically targets the coronary arteries, also unusual for an infectious condition. In this review, we discuss recent hypotheses on KD pathogenesis as well as new insights into the innate immune response and mechanisms behind vascular damage. The pathogenesis is complex, however, and remains inadequately understood.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
Limite:
Animals
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Child, preschool
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Humans
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Infant
Idioma:
En
Revista:
Clin Immunol
Ano de publicação:
2020
Tipo de documento:
Article