Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery.
Brain Res
; 1737: 146797, 2020 06 15.
Article
em En
| MEDLINE
| ID: mdl-32194078
ABSTRACT
BACKGROUND:
Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The underlying mechanisms linking depression and stroke remain unclear. Preclinical models may provide novel insights, but models reflecting both conditions are lacking.METHODS:
In this study, we investigated the effects of a 45-min transient middle cerebral artery occlusion (MCAo) on infarct size in male adult Flinders Sensitive Line rats, a genetic animal model of depression, and their control strains Flinders Resistant Line and Sprague-Dawley rats. Infarct size was assessed by tetrazolium chloride (TTC) and microtubule-associated protein 2 (MAP2) staining after 48 h of reperfusion. Angiograms of the vascular structure of naïve animals were produced with a µ-CT scanner.RESULTS:
Both Flinders strains had significantly smaller infarcts following MCAo compared to Sprague-Dawley rats. This effect does not appear to be due to changes in cerebrovascular architecture, as indicated by an initial exploration of vascular organization using angiograms, or body temperature regulation.CONCLUSIONS:
Our study suggests that the rat strain does not influence infarct volumes following MCAo.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Infarto da Artéria Cerebral Média
/
Modelos Animais de Doenças
/
Infarto
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2020
Tipo de documento:
Article