Chewing augments stress-induced increase of pERK-immunoreactive cells in the rat cingulate cortex.
Neurosci Lett
; 727: 134921, 2020 05 14.
Article
em En
| MEDLINE
| ID: mdl-32201242
ABSTRACT
The eï¬ ;ects of chewing during restraint stress on the anterior, mid- and posterior cingulate cortices were investigated in rats using immunohistochemistry to detect the expression of phosphorylated extracellular signal-regulated kinase 1 and 2 (pERK1/2), a marker of responding cells. The rats were divided into three groups control (no immobilization), stress-only (immobilized), and stress-with-chewing (immobilized and allowed to chew a wooden stick). Significant increases in the number of pERK1/2-immunoreactive cells in the anterior, mid- and posterior cingulate cortices were noted in the stress-only group when compared with the control group (p < 0.05). Furthermore, the number of pERK1/2-immunoreactive cells in the anterior, mid- and posterior cingulate cortices in the stress-with-chewing group was also significantly higher than that in the stress-only group (p < 0.05). These findings indicate that the cingulate cortex plays a role in the negative-feedback effect and might be an essential part of the brain where the ameliorating effects of chewing against stress are produced.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
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Sistema de Sinalização das MAP Quinases
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Giro do Cíngulo
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Mastigação
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2020
Tipo de documento:
Article