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Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae.
Bao, Juan; Wu, Nannan; Zeng, Yigang; Chen, Liguang; Li, Linlin; Yang, Lan; Zhang, Yiyuan; Guo, Mingquan; Li, Lisha; Li, Jie; Tan, Demeng; Cheng, Mengjun; Gu, Jingmin; Qin, Jinghong; Liu, Jiazheng; Li, Shiru; Pan, Guangqiang; Jin, Xin; Yao, Bangxin; Guo, Xiaokui; Zhu, Tongyu; Le, Shuai.
Afiliação
  • Bao J; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Wu N; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Zeng Y; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Chen L; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Li L; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Yang L; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Zhang Y; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Guo M; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Li L; Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Li J; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Tan D; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Cheng M; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Gu J; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Qin J; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Liu J; Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  • Li S; Department of Microbiology, Army Medical University, Chongqing, People's Republic of China.
  • Pan G; Department of Microbiology, Army Medical University, Chongqing, People's Republic of China.
  • Jin X; Department of Pathology, The Second Affiliated Hospital of Army Medical University, Chongqing, People's Republic of China.
  • Yao B; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Guo X; Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
  • Zhu T; Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
  • Le S; Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Emerg Microbes Infect ; 9(1): 771-774, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32212918
ABSTRACT
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail inhibited the emergence of phage resistant mutant in vitro, and the UTI of patient was successfully cured by this combination. Thus, we propose that non-active antibiotic and bacteriophage synergism (NABS) might be an alternative strategy in personalized phage therapy.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Infecções por Klebsiella / Farmacorresistência Bacteriana Múltipla / Terapia por Fagos / Antibacterianos Limite: Female / Humans / Middle aged Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Infecções por Klebsiella / Farmacorresistência Bacteriana Múltipla / Terapia por Fagos / Antibacterianos Limite: Female / Humans / Middle aged Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2020 Tipo de documento: Article