Association between the IL-10 and IL-6 polymorphisms and brucellosis susceptibility: a meta-analysis.
BMC Med Genet
; 21(1): 63, 2020 03 30.
Article
em En
| MEDLINE
| ID: mdl-32228609
ABSTRACT
BACKGROUND:
Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (- 1082 G/A, - 819 C/T, - 592C/A) and IL-6 -174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility.METHODS:
Both OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used.RESULTS:
The significant associations were only found in Asian population of - 819 loci under three genetic models as follows (Allele model OR = 0.60, 95%CI = 0.44-0.82, P = 0.001), (homozygote comparison OR = 0.24, 95%CI = 0.09-0.62, P = 0.003), (recessive genetic model OR = 0.22, 95%CI = 0.05-0.91, P = 0.036).CONCLUSION:
In conclusion, IL-10 - 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10 -1082 G/A, 592 loci and IL-6 -174 G/C polymorphism are not associated with Brucellosis risk.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Brucelose
/
Interleucina-6
/
Interleucina-10
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
BMC Med Genet
Ano de publicação:
2020
Tipo de documento:
Article