Two new diterpenoids with their antiproliferative activities from the supercritical fluid extraction of Croton crassifolius root.
Nat Prod Res
; 35(22): 4479-4485, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-32233665
ABSTRACT
Supercritical fluid extraction was applied to obtain the lower polarity extracts from Croton crassifolius roots, and chemical investigation of which led to the isolation and identification of two new diterpenoids, named crassifolius P (1) and crassifolius Q (2). In vitro anti-proliferative activities of compounds 1 and 2 on A549, Hep-G2 and Hela tumor cell lines were evaluated. The two new compounds exhibited obvious selectivity to tumor cells with IC50 values ranging from 20.43 ± 1.18 µM to 25.72 ± 1.32 µM.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Croton
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Cromatografia com Fluido Supercrítico
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Diterpenos
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2021
Tipo de documento:
Article