A Historic Perspective and Overview of H-Ras Structure, Oncogenicity, and Targeting.
Mol Cancer Ther
; 19(4): 999-1007, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32241873
ABSTRACT
H-Ras is a unique isoform of the Ras GTPase family, one of the most prominently mutated oncogene families across the cancer landscape. Relative to other isoforms, though, mutations of H-Ras account for the smallest proportion of mutant Ras cancers. Yet, in recent years, there have been renewed efforts to study this isoform, especially as certain H-Ras-driven cancers, like those of the head and neck, have become more prominent. Important advances have therefore been made not only in the understanding of H-Ras structural biology but also in approaches designed to inhibit and impair its signaling activity. In this review, we outline historic and present initiatives to elucidate the mechanisms of H-Ras-dependent tumorigenesis as well as highlight ongoing developments in the quest to target this critical oncogene.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas p21(ras)
/
Terapia de Alvo Molecular
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Mutação
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Mol Cancer Ther
Ano de publicação:
2020
Tipo de documento:
Article