Linking bacterial growth, survival, and multicellularity - small signaling molecules as triggers and drivers.
Curr Opin Microbiol
; 55: 57-66, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32244175
ABSTRACT
An overarching theme of cellular regulation in bacteria arises from the trade-off between growth and stress resilience. In addition, the formation of biofilms contributes to stress survival, since these dense multicellular aggregates, in which cells are embedded in an extracellular matrix of self-produced polymers, represent a self-constructed protective and homeostatic 'niche'. As shown here for the model bacterium Escherichia coli, the inverse coordination of bacterial growth with survival and the transition to multicellularity is achieved by a highly integrated regulatory network with several sigma subunits of RNA polymerase and a small number of transcriptional hubs as central players. By conveying information about the actual (micro)environments, nucleotide second messengers such as cAMP, (p)ppGpp, and in particular c-di-GMP are the key triggers and drivers that promote either growth or stress resistance and organized multicellularity in a world of limited resources.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Sistemas do Segundo Mensageiro
/
Biofilmes
/
Proteínas de Escherichia coli
/
Escherichia coli
/
Redes Reguladoras de Genes
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Curr Opin Microbiol
Ano de publicação:
2020
Tipo de documento:
Article