Venoocclusive Disease With Both Hepatic and Pulmonary Involvement.
Chest
; 157(4): e107-e109, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32252933
ABSTRACT
Pulmonary venoocclusive disease (PVOD) is a rare form of pulmonary vascular disease with pulmonary hypertension characterized by preferential involvement of the pulmonary venous system. Hepatic venoocclusive disease (HVOD), also known as sinusoidal obstruction syndrome, is a condition that occurs in 13% to 15% of patients after hematopoietic stem cell transplantation (HSCT). Although hepatic and pulmonary venoocclusive diseases may share some pathologic features as well as some etiologies such as HSCT, these two disorders have never been described together in a single adult patient. We report the case of a patient who received HSCT and developed HVOD and PVOD within 9 months. Despite their differences, PVOD and HVOD share common risk factors and associated conditions, suggesting that in the context of HSCT, the two diseases share common pathophysiological mechanisms. Optimal treatment for HSCT-related PVOD remains to be determined.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilpropionatos
/
Polidesoxirribonucleotídeos
/
Piridazinas
/
Hepatopatia Veno-Oclusiva
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Pneumopatia Veno-Oclusiva
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Transplante de Células-Tronco Hematopoéticas
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Hipertensão Arterial Pulmonar
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Chest
Ano de publicação:
2020
Tipo de documento:
Article