Why Warburg Works: Lactate Controls Immune Evasion through GPR81.

Lundø, Kathrine; Trauelsen, Mette; Pedersen, Stine F; Schwartz, Thue W

Lundø, Kathrine; Trauelsen, Mette; Pedersen, Stine F; Schwartz, Thue W.

Afiliação

Lundø K; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark; Department of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark.
Trauelsen M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark.
Pedersen SF; Department of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: sfpedersen@bio.ku.dk.
Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, The Mærsk Tower, The Panum Institute, 2200 Copenhagen, Denmark. Electronic address: tws@sund.ku.dk.

Cell Metab ; 31(4): 666-668, 2020 04 07.

Article em En | MEDLINE | ID: mdl-32268113

ABSTRACT

ABSTRACT

Lactate accumulation in tumors-a hallmark of the Warburg effect-has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells.

Assuntos

Neoplasias da Mama; Microambiente Tumoral; Células Apresentadoras de Antígenos; Humanos; Evasão da Resposta Imune; Ácido Láctico; Receptores Acoplados a Proteínas G

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Microambiente Tumoral Limite: Humans Idioma: En Revista: Cell Metab Ano de publicação: 2020 Tipo de documento: Article

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