Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior.

Huang, Dehua; Liu, Huiqing; Zhu, Aoxue; Zhou, Yi; Li, Yong

Huang, Dehua; Liu, Huiqing; Zhu, Aoxue; Zhou, Yi; Li, Yong.

Afiliação

Huang D; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China.
Liu H; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China.
Zhu A; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China.
Zhou Y; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Li Y; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China. liyong68@shsmu.edu.cn.

Mol Brain ; 13(1): 59, 2020 04 14.

Article em En | MEDLINE | ID: mdl-32290845

Assuntos

Ansiedade/fisiopatologia; Comportamento Animal; Cisteína Endopeptidases/deficiência; Aprendizagem; Memória; Neurônios/metabolismo; Prosencéfalo/metabolismo; Prosencéfalo/fisiopatologia; Animais; Ansiedade/genética; Ansiedade/metabolismo; Córtex Cerebral/patologia; Córtex Cerebral/fisiopatologia; Cisteína Endopeptidases/genética; Cisteína Endopeptidases/metabolismo; Medo; Regulação da Expressão Gênica; Ontologia Genética; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neurônios/patologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

Anxiety-like behavior; Conditional knockout mice; Learning and memory; RNA-seq; SENP2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Comportamento Animal / Cisteína Endopeptidases / Prosencéfalo / Aprendizagem / Memória / Neurônios Limite: Animals Idioma: En Revista: Mol Brain Ano de publicação: 2020 Tipo de documento: Article

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