Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Pharmacokinetic Evaluation of 7ß-(3-Ethyl-cis-crotonoyloxy)-1&#945;-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranon in Rats.

Kang, Nae-Won; Lee, Jae-Young; Song, Kwangho; Kim, Min-Hwan; Yoon, Soyeon; Nguyen, Duy-Thuc; Kim, Sungho; Kim, Yeong Shik; Kim, Dae-Duk

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Pharmacokinetic Evaluation of 7ß-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranon in Rats.

Kang, Nae-Won; Lee, Jae-Young; Song, Kwangho; Kim, Min-Hwan; Yoon, Soyeon; Nguyen, Duy-Thuc; Kim, Sungho; Kim, Yeong Shik; Kim, Dae-Duk.

Afiliação

Kang NW; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Lee JY; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
Song K; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Kim MH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Yoon S; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Nguyen DT; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Kim S; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
Kim YS; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Kim DD; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.

Molecules ; 25(8)2020 Apr 13.

Article em En | MEDLINE | ID: mdl-32294941

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Extratos Vegetais/farmacocinética; Sesquiterpenos/farmacocinética; Espectrometria de Massas em Tandem/métodos; Acetonitrilas/química; Administração Oral; Animais; Calibragem; Cromatografia Líquida de Alta Pressão/instrumentação; Formiatos/química; Limite de Detecção; Losartan/química; Masculino; Farmacocinética; Extratos Vegetais/sangue; Extratos Vegetais/química; Extratos Vegetais/isolamento & purificação; Controle de Qualidade; Ratos; Ratos Sprague-Dawley; Sesquiterpenos/administração & dosagem; Sesquiterpenos/sangue; Sesquiterpenos/química; Espectrometria de Massas em Tandem/instrumentação; Tussilago/química

Palavras-chave

7ß-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone; Keywords: ECN; LC-MS/MS; Pharmacokinetics; Tussilago farfara Linnaeus; Validation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Extratos Vegetais / Cromatografia Líquida de Alta Pressão / Espectrometria de Massas em Tandem Tipo de estudo: Evaluation_studies Limite: Animals Idioma: En Revista: Molecules Ano de publicação: 2020 Tipo de documento: Article

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