Influence of alcohol consumption on blood coagulation in rotational thromboelastometry (ROTEM): an in-vivo study.
Korean J Anesthesiol
; 73(4): 334-341, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32299155
ABSTRACT
BACKGROUND:
Twenty-five to 85% of trauma patients are under the influence of alcohol in addition to experiencing injury-related coagulation impairment. Viscoelastic point-of-care tests (thrombelastography [TEG], rotational thromboelastometry [ROTEM]) are popular tools for rapid hemostasis assessment and therapeutic decision-making in this and other settings. While alcohol affects these tests in-vitro, their specific effects in-vivo are unclear. Therefore, we evaluated the effects of alcohol ingestion on ROTEM parameters.METHODS:
Twenty volunteers provided informed consent to drinking red wine, whisk(e)y, or vodka to a target blood alcohol concentration of 1 within one hour, calculated with the Widmark formula. Blood samples were collected before drinking, at a breath alcohol concentration of 0.5 , and at 1.0 , but no later than one hour. After each blood collection, ExTEM and FibTEM tests were performed directly "at the bedside."RESULTS:
All participants had a blood alcohol concentration (BAC) of 0.00 at the beginning. The mean BACs at the second and third collection were 0.48 and 0.76 , respectively. There were no significant differences in the ExTEM parameters. FibTEM measurements showed a significant difference at the A10 value (13.0 vs. 14.0 mm, P = 0.014) and a trend at the maximum amplitude (maximum clot firmness [MCF] 13.7 vs. 16.2 mm, P = 0.075). We saw no significant differences in fibrinolysis parameters and no hyperfibrinolysis in our ROTEM measurements.CONCLUSIONS:
Ethanol ingestion can impair early fibrin polymerization. These results might be of special relevance in trauma and support routine application of ROTEM/TEG in such cases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tromboelastografia
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Coagulação Sanguínea
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Consumo de Bebidas Alcoólicas
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Concentração Alcoólica no Sangue
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Korean J Anesthesiol
Ano de publicação:
2020
Tipo de documento:
Article