Development of new self-assembled cationic amino liposomes for efficient gene delivery.

Wu, Yihang; Xiong, Yue; Wang, Ling; Zhou, Quanming; Li, Linxian; Levkin, Pavel A; Davidson, Gary; Gao, Liqian; Deng, Wenbin

Wu, Yihang; Xiong, Yue; Wang, Ling; Zhou, Quanming; Li, Linxian; Levkin, Pavel A; Davidson, Gary; Gao, Liqian; Deng, Wenbin.

Afiliação

Wu Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, P.R. China. gaolq@mail.sysu.edu.cn glqustc@gmail.com dengwb5@mail.sysu.edu.cn.

Biomater Sci ; 8(11): 3021-3025, 2020 Jun 07.

Article em En | MEDLINE | ID: mdl-32322846

ABSTRACT

ABSTRACT

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.

Assuntos

DNA/administração & dosagem; Técnicas de Transferência de Genes; RNA Interferente Pequeno/administração & dosagem; Animais; Cátions; Linhagem Celular; Sobrevivência Celular; Fibroblastos/metabolismo; Humanos; Lipossomos; Camundongos; Células-Tronco Embrionárias Murinas/metabolismo; Plasmídeos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Técnicas de Transferência de Genes / RNA Interferente Pequeno Limite: Animals / Humans Idioma: En Revista: Biomater Sci Ano de publicação: 2020 Tipo de documento: Article

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