Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.

Arrieta, Adrian; Blackwood, Erik A; Stauffer, Winston T; Santo Domingo, Michelle; Bilal, Alina S; Thuerauf, Donna J; Pentoney, Amber N; Aivati, Cathrine; Sarakki, Anup V; Doroudgar, Shirin; Glembotski, Christopher C

Arrieta, Adrian; Blackwood, Erik A; Stauffer, Winston T; Santo Domingo, Michelle; Bilal, Alina S; Thuerauf, Donna J; Pentoney, Amber N; Aivati, Cathrine; Sarakki, Anup V; Doroudgar, Shirin; Glembotski, Christopher C.

Afiliação

Arrieta A; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Blackwood EA; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Stauffer WT; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Santo Domingo M; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Bilal AS; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Thuerauf DJ; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Pentoney AN; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Aivati C; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Sarakki AV; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Doroudgar S; San Diego State University Heart Institute and the Department of Biology, San Diego State University, San Diego, California, USA.
Glembotski CC; Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, Innere Medizin III, Heidelberg, Germany.

J Biol Chem ; 295(22): 7566-7583, 2020 05 29.

Article em En | MEDLINE | ID: mdl-32327487

Assuntos

Estresse do Retículo Endoplasmático; Retículo Endoplasmático/metabolismo; Chaperonas Moleculares/metabolismo; Traumatismo por Reperfusão Miocárdica/metabolismo; Miocárdio/metabolismo; Miócitos Cardíacos/metabolismo; Fatores de Crescimento Neural/metabolismo; Animais; Sobrevivência Celular; Retículo Endoplasmático/genética; Retículo Endoplasmático/patologia; Glicosilação; Células HeLa; Humanos; Camundongos; Camundongos Knockout; Chaperonas Moleculares/genética; Traumatismo por Reperfusão Miocárdica/genética; Traumatismo por Reperfusão Miocárdica/patologia; Miocárdio/patologia; Miócitos Cardíacos/patologia; Fatores de Crescimento Neural/genética; Espécies Reativas de Oxigênio

Palavras-chave

cardiomyocyte; chaperone; endoplasmic reticulum stress (ER stress); heart function; ischemia; ischemia/reperfusion; mesencephalic astrocyte-derived neurotrophic factor (MANF); protein folding; reductive stress; unfolded protein response

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 6_ODS3_enfermedades_notrasmisibles / 7_ODS3_muertes_prevenibles_nacidos_ninos Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Chaperonas Moleculares / Miócitos Cardíacos / Retículo Endoplasmático / Estresse do Retículo Endoplasmático / Miocárdio / Fatores de Crescimento Neural Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article

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