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CYP3A subfamily activity affects the equilibrium concentration of Phenazepam® in patients with anxiety disorders and comorbid alcohol use disorder.
Zastrozhin, Mikhail Sergeevich; Skryabin, Valentin Yurievich; Sorokin, Alexander Sergeevich; Petukhov, Aleksey Evgenievich; Smirnov, Valery Valerievich; Pankratenko, Ekaterina Petrovna; Grishina, Elena Anatolievna; Ryzhikova, Kristina Anatolievna; Panov, Aleksey Sergeevich; Savchenko, Ludmila Mikhailovna; Bryun, Evgeny Alekseevich; Sychev, Dmitry Alekseevich.
Afiliação
  • Zastrozhin MS; Laboratory of Genetics & Genomics, Moscow Research & Practical Centre on Addictions of The Moscow Department of Healthcare, Moscow, 109390, Russian Federation.
  • Skryabin VY; Department of Addictology, Russian Medical Academy of Continuous Professional Education of The Ministry of Health of The Russian Federation, Moscow, 123995, Russian Federation.
  • Sorokin AS; Laboratory of Genetics & Genomics, Moscow Research & Practical Centre on Addictions of The Moscow Department of Healthcare, Moscow, 109390, Russian Federation.
  • Petukhov AE; Laboratory of Genetics & Genomics, Moscow Research & Practical Centre on Addictions of The Moscow Department of Healthcare, Moscow, 109390, Russian Federation.
  • Smirnov VV; Laboratory of Genetics & Genomics, Moscow Research & Practical Centre on Addictions of The Moscow Department of Healthcare, Moscow, 109390, Russian Federation.
  • Pankratenko EP; Laboratory of Clinical Pharmacology, National Research Centre - Institute of Immunology of The Federal Biomedical Agency of The Russian Federation, Moscow, 115478, Russian Federation.
  • Grishina EA; Department of Pharmaceutical and Toxicological Chemistry A.P. Arzamastseva, I.M. Sechenov First Moscow State Medical University of The Ministry of Health of The Russian Federation (Sechenov University), Moscow, 119991, Russia.
  • Ryzhikova KA; Laboratory of Genetics & Genomics, Moscow Research & Practical Centre on Addictions of The Moscow Department of Healthcare, Moscow, 109390, Russian Federation.
  • Panov AS; Department of Addictology, Russian Medical Academy of Continuous Professional Education of The Ministry of Health of The Russian Federation, Moscow, 123995, Russian Federation.
  • Savchenko LM; Department of Addictology, Russian Medical Academy of Continuous Professional Education of The Ministry of Health of The Russian Federation, Moscow, 123995, Russian Federation.
  • Bryun EA; Department of Addictology, Russian Medical Academy of Continuous Professional Education of The Ministry of Health of The Russian Federation, Moscow, 123995, Russian Federation.
  • Sychev DA; Department of Addictology, Russian Medical Academy of Continuous Professional Education of The Ministry of Health of The Russian Federation, Moscow, 123995, Russian Federation.
Pharmacogenomics ; 21(7): 449-457, 2020 05.
Article em En | MEDLINE | ID: mdl-32336193
ABSTRACT
Phenazepam® is prescribed to relieve anxiety and sleep disorders during alcohol withdrawal, although it is associated with undesirable side effects.

Aim:

To demonstrate changes in the safety and efficacy profiles of Phenazepam in patients with anxiety disorders and comorbid alcohol use disorder. Materials &

methods:

A total of 94 Russian patients with alcohol use disorder received 4.0 mg of Phenazepam per day in tablets. We used a urinary 6-beta-hydroxycortisol/cortisol ratio to evaluate CYP3A activity.

Results:

A statistically significant inverse correlation between Phenazepam plasma concentration and CYP3A activity was found (r = -0.340 and p = 0.017). Correlation between the concentration/dose ratio and phenotyping results was also statistically significant (r = 0.301 and p = 0.026).

Conclusion:

The safety and efficacy of Phenazepam depend on CYP3A genetic polymorphisms.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Benzodiazepinas / Alcoolismo / Citocromo P-450 CYP3A Limite: Adult / Female / Humans / Male País/Região como assunto: Asia / Europa Idioma: En Revista: Pharmacogenomics Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Benzodiazepinas / Alcoolismo / Citocromo P-450 CYP3A Limite: Adult / Female / Humans / Male País/Região como assunto: Asia / Europa Idioma: En Revista: Pharmacogenomics Ano de publicação: 2020 Tipo de documento: Article