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FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1.
Fan, Guo-Hua; Zhu, Tie-Yuan; Huang, Jie.
Afiliação
  • Fan GH; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Zhu TY; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: tieyuan_zhu@163.com.
  • Huang J; Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Cell Signal ; 72: 109665, 2020 08.
Article em En | MEDLINE | ID: mdl-32353410
ABSTRACT
Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinicopathological characteristics in patients with NSCLCs. However, the role and potential molecular basis for FNDC5 in paclitaxel sensitivity of NSCLCs remain unclear. Paclitaxel-sensitive or resistant NSCLCs cell lines were exposed to small interfering RNA against FNDC5 (siFndc5) or recombinant irisin in the presence or absence of paclitaxel. NSCLCs cell lines have decreased FNDC5 expression compared with the normal human lung epithelial cells, which was further downregulated in paclitaxel-resistant cells. Irisin treatment suppressed, whereas Fndc5 silence promoted NSCLCs cells proliferation under basal conditions. Besides, we found that FNDC5 increased paclitaxel chemosensitivity in paclitaxel-sensitive or resistant NSCLCs cell lines via downregulating multidrug resistance protein 1 (MDR1). Further studies revealed that FNDC5 inhibited MDR1 expression via blocking nuclear factor-κB (NF-κB) activation. FNDC5 promotes paclitaxel sensitivity of NSCLCs cells via inhibiting NF-κB/MDR1 signaling, and FNDC5 might be a novel therapeutic target for the treatment of NSCLCs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibronectinas / Paclitaxel / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Cell Signal Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibronectinas / Paclitaxel / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Cell Signal Ano de publicação: 2020 Tipo de documento: Article