Developmental Consequences of Prenatal Telbivudine Exposure during the Third Trimester.
Clin Gastroenterol Hepatol
; 19(5): 1061-1063, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-32371166
ABSTRACT
Hepatitis B virus (HBV) infection is a global health issue. Mother-to-child transmission (MTCT) is the most prominent route for chronic HBV infection in Asian countries.1 Although standard immunoprophylaxis has been effective in preventing MTCT, a significantly higher rate of MTCT has been observed among mothers with high levels of viremia.2 Tenofovir disoproxil, telbivudine (LdT), and lamivudine, used in third trimester, have been shown to significantly reduce MTCT of HBV for highly viremic mothers.3 Although the efficacy and short-term safety of LdT in preventing MTCT have been demonstrated in several large cohort studies in recent years, fewer data exist on the safety assessment of infants' neurocognitive development after fetal exposure to LdT.4-6 Therefore, we conducted a prospective cohort study to investigate the effect of LdT on infants' neurocognitive development.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Hepatite B Crônica
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Revista:
Clin Gastroenterol Hepatol
Ano de publicação:
2021
Tipo de documento:
Article