Predicting Method for the Human Plasma Concentration-Time Profile of a Monoclonal Antibody from the Half-life of Non-human Primates.

Nakamura, Genki; Ozeki, Kazuhisa; Nagayasu, Miho; Nambu, Takeru; Nemoto, Takayuki; Hosoya, Ken-Ichi

Nakamura, Genki; Ozeki, Kazuhisa; Nagayasu, Miho; Nambu, Takeru; Nemoto, Takayuki; Hosoya, Ken-Ichi.

Afiliação

Nakamura G; Research Division, Chugai Pharmaceutical Co., Ltd.
Ozeki K; Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.
Nagayasu M; Research Division, Chugai Pharmaceutical Co., Ltd.
Nambu T; Research Division, Chugai Pharmaceutical Co., Ltd.
Nemoto T; Research Division, Chugai Pharmaceutical Co., Ltd.
Hosoya KI; Research Division, Chugai Pharmaceutical Co., Ltd.

Biol Pharm Bull ; 43(5): 823-830, 2020.

Article em En | MEDLINE | ID: mdl-32378559

Assuntos

Anticorpos Monoclonais/farmacocinética; Modelos Biológicos; Administração Intravenosa; Animais; Anticorpos Monoclonais/sangue; Avaliação Pré-Clínica de Medicamentos; Meia-Vida; Humanos; Macaca fascicularis; Macaca mulatta

Palavras-chave

clinical pharmacokinetics; monoclonal antibody; preclinical pharmacokinetics; simulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Biológicos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Biol Pharm Bull Ano de publicação: 2020 Tipo de documento: Article

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