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Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.
Mock, Elliot D; Mustafa, Mohammed; Gunduz-Cinar, Ozge; Cinar, Resat; Petrie, Gavin N; Kantae, Vasudev; Di, Xinyu; Ogasawara, Daisuke; Varga, Zoltan V; Paloczi, Janos; Miliano, Cristina; Donvito, Giulia; van Esbroeck, Annelot C M; van der Gracht, Anouk M F; Kotsogianni, Ioli; Park, Joshua K; Martella, Andrea; van der Wel, Tom; Soethoudt, Marjolein; Jiang, Ming; Wendel, Tiemen J; Janssen, Antonius P A; Bakker, Alexander T; Donovan, Colleen M; Castillo, Laura I; Florea, Bogdan I; Wat, Jesse; van den Hurk, Helma; Wittwer, Matthias; Grether, Uwe; Holmes, Andrew; van Boeckel, Constant A A; Hankemeier, Thomas; Cravatt, Benjamin F; Buczynski, Matthew W; Hill, Matthew N; Pacher, Pal; Lichtman, Aron H; van der Stelt, Mario.
Afiliação
  • Mock ED; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Mustafa M; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
  • Gunduz-Cinar O; Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA), National Institute of Health (NIH), Bethesda, MD, USA.
  • Cinar R; Laboratory of Physiologic Studies, NIAAA, NIH, Bethesda, MD, USA.
  • Petrie GN; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
  • Kantae V; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Di X; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
  • Ogasawara D; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
  • Varga ZV; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
  • Paloczi J; Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA, NIH, Bethesda, MD, USA.
  • Miliano C; Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA, NIH, Bethesda, MD, USA.
  • Donvito G; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
  • van Esbroeck ACM; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
  • van der Gracht AMF; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Kotsogianni I; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Park JK; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Martella A; Laboratory of Physiologic Studies, NIAAA, NIH, Bethesda, MD, USA.
  • van der Wel T; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Soethoudt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Jiang M; Oncode Institute, Leiden, the Netherlands.
  • Wendel TJ; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Janssen APA; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Bakker AT; Oncode Institute, Leiden, the Netherlands.
  • Donovan CM; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Castillo LI; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Florea BI; Oncode Institute, Leiden, the Netherlands.
  • Wat J; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • van den Hurk H; Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA), National Institute of Health (NIH), Bethesda, MD, USA.
  • Wittwer M; Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA), National Institute of Health (NIH), Bethesda, MD, USA.
  • Grether U; Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Holmes A; Pivot Park Screening Centre B.V., Oss, the Netherlands.
  • van Boeckel CAA; Pivot Park Screening Centre B.V., Oss, the Netherlands.
  • Hankemeier T; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd, Basel, Switzerland.
  • Cravatt BF; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd, Basel, Switzerland.
  • Buczynski MW; Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA), National Institute of Health (NIH), Bethesda, MD, USA.
  • Hill MN; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
  • Pacher P; Pivot Park Screening Centre B.V., Oss, the Netherlands.
  • Lichtman AH; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
  • van der Stelt M; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
Nat Chem Biol ; 16(6): 667-675, 2020 06.
Article em En | MEDLINE | ID: mdl-32393901
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidiletanolaminas / Fosfolipase D / Comportamento Animal / Inibidores Enzimáticos / Metabolismo dos Lipídeos Limite: Animals / Humans / Male Idioma: En Revista: Nat Chem Biol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidiletanolaminas / Fosfolipase D / Comportamento Animal / Inibidores Enzimáticos / Metabolismo dos Lipídeos Limite: Animals / Humans / Male Idioma: En Revista: Nat Chem Biol Ano de publicação: 2020 Tipo de documento: Article