Cholesterol and Egg Intakes, and Risk of Hypertension in a Large Prospective Cohort of French Women.
Nutrients
; 12(5)2020 May 08.
Article
em En
| MEDLINE
| ID: mdl-32397298
ABSTRACT
Purpose:
The relationship between egg and cholesterol intakes, and cardiovascular disease is controversial. Meta-analyses indicate that egg consumption is associated with increased cardiovascular disease and mortality, but reduced incidence of hypertension, a major risk factor for cardiovascular disease. This study aims to investigate the associations between consumption of egg and cholesterol, and hypertension risk in a cohort of French women.Methods:
We used data from the E3N cohort study, a French prospective population-based study initiated in 1990. From the women in the study, we included those who completed a detailed diet history questionnaire, and who did not have prevalent hypertension or cardiovascular disease at baseline, resulting in 46,424 women. Hypertension cases were self-reported. Egg and cholesterol intake was estimated from dietary history questionnaires. Cox proportional hazard models with time-updated exposures were used to calculate hazard ratios. Spline regression was used to determine any dose-respondent relationship.Results:
During 885,321 person years, 13,161 cases of incident hypertension were identified. Higher cholesterol consumption was associated with an increased risk of hypertension HRQ1-Q5 = 1.22 [1.141.30], with associations similar regarding egg consumption up to seven eggs per week HR4-7 eggs = 1.14 [1.061.18]. Evidence for a non-linear relationship between hypertension and cholesterol intake was observed.Conclusion:
Egg and cholesterol intakes were associated with a higher risk of hypertension in French women. These results merit further investigation in other populations.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Colesterol na Dieta
/
Ingestão de Alimentos
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Ovos
/
Hipertensão
/
Fenômenos Fisiológicos da Nutrição
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Nutrients
Ano de publicação:
2020
Tipo de documento:
Article