Ephrin-B2 paces neuronal production in the developing neocortex.
BMC Dev Biol
; 20(1): 12, 2020 05 13.
Article
em En
| MEDLINE
| ID: mdl-32404061
ABSTRACT
BACKGROUND:
During mammalian cerebral cortex development, different types of projection neurons are produced in a precise temporal order and in stereotypical numbers. The mechanisms regulating timely generation of neocortex projection neurons and ensuring production in sufficient numbers of each neuronal identity are only partially understood.RESULTS:
Here, we show that ephrin-B2, a member of the Ephephrin cell-to-cell communication pathway, sets the neurogenic tempo in the neocortex. Indeed, conditional mutant embryos for ephrin-B2 exhibit a transient delay in neurogenesis and acute stimulation of Eph signaling by in utero injection of synthetic ephrin-B2 led to a transient increase in neuronal production. Using genetic approaches we show that ephrin-B2 acts on neural progenitors to control their differentiation in a juxtacrine manner. Unexpectedly, we observed that perinatal neuron numbers recovered following both loss and gain of ephrin-B2, highlighting the ability of neural progenitors to adapt their behavior to the state of the system in order to produce stereotypical numbers of neurons.CONCLUSIONS:
Altogether, our data uncover a role for ephrin-B2 in embryonic neurogenesis and emphasize the plasticity of neuronal production in the neocortex.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neocórtex
/
Efrina-B2
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
BMC Dev Biol
Ano de publicação:
2020
Tipo de documento:
Article