Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway.

Ban, Liuxian; Mei, Ting; Su, Qiao; Li, Wuguo; Huang, Zhexun; Liu, Lin; Wu, Yu; Lv, Shaowen; Wang, Anxun; Li, Su

Ban, Liuxian; Mei, Ting; Su, Qiao; Li, Wuguo; Huang, Zhexun; Liu, Lin; Wu, Yu; Lv, Shaowen; Wang, Anxun; Li, Su.

Afiliação

Ban L; Department of Clinical Trial, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China.
Mei T; Department of Clinical Trial, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China.
Su Q; Animal Experiment Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China.
Li W; Animal Experiment Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China.
Huang Z; Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China.
Liu L; Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China.
Wu Y; Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China.
Lv S; Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China.
Wang A; Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China. Electronic address: anxunwang@yahoo.com.
Li S; Department of Clinical Trial, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China. Electronic address: lisu@sysucc.org.cn.

Life Sci ; 254: 117695, 2020 Aug 01.

Article em En | MEDLINE | ID: mdl-32407849

Assuntos

Antifúngicos/farmacologia; Antineoplásicos/farmacologia; Carcinoma de Células Escamosas/patologia; Proteínas Hedgehog/antagonistas & inibidores; Itraconazol/farmacologia; Neoplasias Bucais/patologia; Apoptose/efeitos dos fármacos; Carcinoma de Células Escamosas/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proteínas Hedgehog/metabolismo; Humanos; Neoplasias Bucais/metabolismo

Palavras-chave

Hedgehog pathway; Itraconazole; Oral squamous cell carcinoma; Patient-Derived Xenograft

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Itraconazol / Proteínas Hedgehog / Antifúngicos / Antineoplásicos Limite: Humans Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article

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