Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C.

Lin, Yi-Pin; Tan, Xi; Caine, Jennifer A; Castellanos, Mildred; Chaconas, George; Coburn, Jenifer; Leong, John M

Lin, Yi-Pin; Tan, Xi; Caine, Jennifer A; Castellanos, Mildred; Chaconas, George; Coburn, Jenifer; Leong, John M.

Afiliação

Lin YP; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.
Tan X; Division of Infectious Diseases, New York State Department of Health, Wadsworth Center, Albany, New York, United States of America.
Caine JA; Departments of Biochemistry & Molecular Biology and Microbiology, Immunology & Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Castellanos M; Division of Infectious Diseases, and Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Chaconas G; Departments of Biochemistry & Molecular Biology and Microbiology, Immunology & Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Coburn J; Departments of Biochemistry & Molecular Biology and Microbiology, Immunology & Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Leong JM; Division of Infectious Diseases, and Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.

PLoS Pathog ; 16(5): e1008516, 2020 05.

Article em En | MEDLINE | ID: mdl-32413091

Assuntos

Borrelia burgdorferi/metabolismo; Dermatan Sulfato/metabolismo; Matriz Extracelular/metabolismo; Artropatias/metabolismo; Articulações/metabolismo; Doença de Lyme/metabolismo; Animais; Antígenos de Bactérias; Aderência Bacteriana; Proteínas da Membrana Bacteriana Externa; Borrelia burgdorferi/genética; Borrelia burgdorferi/patogenicidade; Dermatan Sulfato/genética; Matriz Extracelular/genética; Matriz Extracelular/microbiologia; Matriz Extracelular/patologia; Feminino; Fibronectinas/genética; Fibronectinas/metabolismo; Artropatias/genética; Artropatias/microbiologia; Artropatias/patologia; Articulações/microbiologia; Articulações/patologia; Doença de Lyme/genética; Doença de Lyme/microbiologia; Doença de Lyme/patologia; Camundongos; Camundongos SCID; Mutação; Especificidade de Órgãos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Lyme / Borrelia burgdorferi / Dermatan Sulfato / Matriz Extracelular / Artropatias / Articulações Limite: Animals Idioma: En Revista: PLoS Pathog Ano de publicação: 2020 Tipo de documento: Article

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