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Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells.
Bowyer, Georgina; Sharpe, Hannah; Venkatraman, Navin; Ndiaye, Pierre Birahim; Wade, Djibril; Brenner, Nicole; Mentzer, Alex; Mair, Catherine; Waterboer, Tim; Lambe, Teresa; Dieye, Tandakha; Mboup, Souleymane; Hill, Adrian V S; Ewer, Katie J.
Afiliação
  • Bowyer G; The Jenner Institute, University of Oxford, Oxford, UK.
  • Sharpe H; The Jenner Institute, University of Oxford, Oxford, UK.
  • Venkatraman N; The Jenner Institute, University of Oxford, Oxford, UK.
  • Ndiaye PB; Centre Hospitalier Universitaire le Dantec, Dakar, Senegal.
  • Wade D; Centre Hospitalier Universitaire le Dantec, Dakar, Senegal.
  • Brenner N; Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Mentzer A; The Jenner Institute, University of Oxford, Oxford, UK.
  • Mair C; The Jenner Institute, University of Oxford, Oxford, UK.
  • Waterboer T; Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Lambe T; The Jenner Institute, University of Oxford, Oxford, UK.
  • Dieye T; Centre Hospitalier Universitaire le Dantec, Dakar, Senegal.
  • Mboup S; Centre Hospitalier Universitaire le Dantec, Dakar, Senegal.
  • Hill AVS; The Jenner Institute, University of Oxford, Oxford, UK.
  • Ewer KJ; The Jenner Institute, University of Oxford, Oxford, UK.
J Exp Med ; 217(7)2020 07 06.
Article em En | MEDLINE | ID: mdl-32413101
CMV is associated with immunosenescence and reduced vaccine responses in the elderly (>70 yr). However, the impact of CMV in young adults is less clear. In this study, healthy UK and Senegalese adults aged 18-50 yr (average, 29 yr) were vaccinated with the Ebola vaccine candidate chimpanzee adenovirus type 3-vectored Ebola Zaire vaccine (ChAd3-EBO-Z) and boosted with modified vaccinia Ankara Ebola Zaire-vectored (MVA-EBO-Z) vaccine. CMV carriage was associated with an expansion of phenotypically senescent CD4+ and CD8+ T cells expressing CD57 and killer cell lectin-like receptor G1 (KLRG1), which was negatively associated with vaccine responses in both cohorts. Ebola-specific T cell responses induced by vaccination also contained significantly increased frequencies of terminally differentiated CD57+KLRG1+ cells in CMV seropositive (CMV+) individuals. This study suggests that CMV can also affect vaccine responses in younger adults and may have a particularly marked impact in many developing countries where CMV seroprevalence is almost universal.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Imunológicos / Linfócitos T / Infecções por Citomegalovirus / Antígenos CD57 / Lectinas Tipo C / Vacinas contra Ebola Limite: Adult / Humans / Middle aged Idioma: En Revista: J Exp Med Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Imunológicos / Linfócitos T / Infecções por Citomegalovirus / Antígenos CD57 / Lectinas Tipo C / Vacinas contra Ebola Limite: Adult / Humans / Middle aged Idioma: En Revista: J Exp Med Ano de publicação: 2020 Tipo de documento: Article