A direct look at the dysfunction and pathology of the ß cells in human type 2 diabetes.
Semin Cell Dev Biol
; 103: 83-93, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32417220
ABSTRACT
ß cells uniquely produce and secrete insulin under the control of several, integrated signals, to maintain blood glucose concentrations within a narrow physiological interval. ß cell failure is key to the onset and progression of type 2 diabetes, due to impaired function and reduced mass. In this review we focus on several features of human ß cell dysfunction and pathology in type 2 diabetes, as revealed by direct assessment of isolated islet traits and examination of pancreatic tissue from organ donors, surgical samples or autoptic specimens. Insulin secretion defects and pathology findings are discussed in relation to some of the major underlying mechanisms, to also provide clues for conceiving better prevention and treatment of type 2 diabetes by targeting the pancreatic ß cells.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
Limite:
Humans
Idioma:
En
Revista:
Semin Cell Dev Biol
Ano de publicação:
2020
Tipo de documento:
Article