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An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3.
Yang, Jing-Ming; Liu, Ya-Yue; Yang, Wen-Cong; Ma, Xiao-Xiang; Nie, Ying-Ying; Glukhov, Evgenia; Gerwick, Lena; Gerwick, William H; Lei, Xiao-Ling; Zhang, Yi.
Afiliação
  • Yang JM; College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China.
  • Liu YY; Marine Medicine Research and Development Center, Shenzhen Institute of Guangdong Ocean University , Shenzhen, China.
  • Yang WC; College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China.
  • Ma XX; College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China.
  • Nie YY; College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China.
  • Glukhov E; Marine Medicine Research and Development Center, Shenzhen Institute of Guangdong Ocean University , Shenzhen, China.
  • Gerwick L; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California , San Diego, CA, USA.
  • Gerwick WH; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California , San Diego, CA, USA.
  • Lei XL; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California , San Diego, CA, USA.
  • Zhang Y; College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China.
Biosci Biotechnol Biochem ; 84(8): 1546-1553, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32434451
ABSTRACT
A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2-6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4'-hydroxy-6,7-dimethoxyisoflavone), and 5-7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus / Glycine max / Lipopolissacarídeos / Isoflavonas / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus / Glycine max / Lipopolissacarídeos / Isoflavonas / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Ano de publicação: 2020 Tipo de documento: Article