Enantiomeric analysis of clenbuterol in Chinese people by LC-MS/MS to distinguish doping abuse from meat contamination.
Bioanalysis
; 12(11): 783-790, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32441534
ABSTRACT
Aim:
Follow-up investigations are often required for clenbuterol-positive cases. A method to distinguish doping abuse from meat contamination was developed. Materials &methods:
A total of 26 volunteers were recruited to ingest clenbuterol contaminated-pork and clenbuterol tablets.Results:
For 20 volunteers, after ingestion of contaminated-pork, R-(-)/S-(+)-clenbuterol ratio was <1.0, while the value was >1.0 after taking clenbuterol tablets. However, after taking clenbuterol tablets, some ratio points of the other six volunteers were between 0.9 and 1.0. A case of an abnormal cold and fever, which returned to normal after recovery, was also reported firstly.Conclusion:
A change in R-(-)/S-(+)-clenbuterol was reported in the Chinese population initially. A ratio of 0.9 was recommended in doping related cases for the Chinese population.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Contaminação de Alimentos
/
Detecção do Abuso de Substâncias
/
Clembuterol
/
Dopagem Esportivo
/
Substâncias para Melhoria do Desempenho
/
Carne
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Bioanalysis
Ano de publicação:
2020
Tipo de documento:
Article