Development of Specific Fluorogenic Substrates for Human ß-N-Acetyl-D-hexosaminidase A for Cell-Based Assays.

Miura, Kazuki; Aoyama, Yuka; Natsu, Yurika; Koyama, Ryosuke; Hirano, Takako; Nishio, Toshiyuki; Hakamata, Wataru

Miura, Kazuki; Aoyama, Yuka; Natsu, Yurika; Koyama, Ryosuke; Hirano, Takako; Nishio, Toshiyuki; Hakamata, Wataru.

Afiliação

Miura K; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.
Aoyama Y; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.
Natsu Y; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.
Koyama R; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.
Hirano T; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.
Nishio T; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.
Hakamata W; Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University.

Chem Pharm Bull (Tokyo) ; 68(6): 526-533, 2020.

Article em En | MEDLINE | ID: mdl-32475856

Assuntos

Corantes Fluorescentes/química; Imagem Óptica; beta-N-Acetil-Hexosaminidases/análise; Corantes Fluorescentes/síntese química; Células HeLa; Humanos; Modelos Moleculares; Estrutura Molecular; beta-N-Acetil-Hexosaminidases/metabolismo

Palavras-chave

fluorogenic substrate; inhibitor screening; lysosomal storage disease; pharmacological chaperone; ß-N-acetyl-D-hexosaminidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-N-Acetil-Hexosaminidases / Imagem Óptica / Corantes Fluorescentes Limite: Humans Idioma: En Revista: Chem Pharm Bull (Tokyo) Ano de publicação: 2020 Tipo de documento: Article

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