Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course.

Seyhan, Attila A; Gregory, Bernard; Cribbs, Adam P; Bhalara, Sundeept; Li, Yizheng; Loreth, Christine; Zhang, Ying; Guo, Yongjing; Lin, Lih-Ling; Feldmann, Marc; Williams, Lynn M; Brennan, Fionula M; Taylor, Peter C

Seyhan, Attila A; Gregory, Bernard; Cribbs, Adam P; Bhalara, Sundeept; Li, Yizheng; Loreth, Christine; Zhang, Ying; Guo, Yongjing; Lin, Lih-Ling; Feldmann, Marc; Williams, Lynn M; Brennan, Fionula M; Taylor, Peter C.

Afiliação

Seyhan AA; Pfizer, Worldwide Research, Development and Medical, Cambridge, MA, USA.
Gregory B; Joint Program in Cancer Biology, Brown University and Lifespan Cancer Institute and Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, 02903, USA.
Cribbs AP; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, OX3 7FY, United Kingdom.
Bhalara S; Botnar Research Centre, Windmill Road, Headington, Oxford, OX3 7LD, United Kingdom.
Li Y; Watford General Hospital, West Herts NHS Trust, Watford, Herts, UK.
Loreth C; Pfizer, Worldwide Research, Development and Medical, Cambridge, MA, USA.
Zhang Y; Pfizer, Worldwide Research, Development and Medical, Cambridge, MA, USA.
Guo Y; Pfizer, Worldwide Research, Development and Medical, Cambridge, MA, USA.
Lin LL; Pfizer, Worldwide Research, Development and Medical, Cambridge, MA, USA.
Feldmann M; Pfizer, Worldwide Research, Development and Medical, Cambridge, MA, USA.
Williams LM; Immunology and Inflammation, Sanofi, Paris, France.
Brennan FM; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, OX3 7FY, United Kingdom.
Taylor PC; Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, OX3 7FY, United Kingdom.

Sci Rep ; 10(1): 8830, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32483203

Assuntos

Artralgia/sangue; Artrite/sangue; Interferon Tipo I/sangue; Transcriptoma; Adulto; Idoso; Idoso de 80 Anos ou mais; Área Sob a Curva; Artralgia/diagnóstico; Artralgia/genética; Artrite/diagnóstico; Artrite/genética; Artrite Reumatoide/sangue; Artrite Reumatoide/diagnóstico; Artrite Reumatoide/genética; Biomarcadores; Estudos de Casos e Controles; Diagnóstico Diferencial; Feminino; Ontologia Genética; Humanos; Masculino; Análise em Microsséries; Pessoa de Meia-Idade; Curva ROC; Reação em Cadeia da Polimerase em Tempo Real

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite / Interferon Tipo I / Artralgia / Transcriptoma Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article

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