Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase.

Muddala, N Prasad; White, John C; Nammalwar, Baskar; Pratt, Ian; Thomas, Leonard M; Bunce, Richard A; Berlin, K Darrell; Bourne, Christina R

Muddala, N Prasad; White, John C; Nammalwar, Baskar; Pratt, Ian; Thomas, Leonard M; Bunce, Richard A; Berlin, K Darrell; Bourne, Christina R.

Afiliação

Muddala NP; Department of Chemistry, Oklahoma State University, 107 Physical Sciences I, Stillwater, OK, 74078, USA.
White JC; Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
Nammalwar B; Department of Chemistry, Oklahoma State University, 107 Physical Sciences I, Stillwater, OK, 74078, USA.
Pratt I; Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
Thomas LM; Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
Bunce RA; Department of Chemistry, Oklahoma State University, 107 Physical Sciences I, Stillwater, OK, 74078, USA.
Berlin KD; Department of Chemistry, Oklahoma State University, 107 Physical Sciences I, Stillwater, OK, 74078, USA.
Bourne CR; Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA. Electronic address: cbourne@ou.edu.

Eur J Med Chem ; 200: 112412, 2020 Aug 15.

Article em En | MEDLINE | ID: mdl-32502861

Assuntos

Desenho de Fármacos; Inibidores Enzimáticos/química; Staphylococcus aureus/enzimologia; Tetra-Hidrofolato Desidrogenase/química; Sítios de Ligação; Testes de Sensibilidade Microbiana; Relação Estrutura-Atividade; Trimetoprima/análogos & derivados; Trimetoprima/química

Palavras-chave

2,4-Diaminopyrimidine; Alkyl dihydrophthalazines; Antibacterial; Dihydrofolate reductase; Enzyme inhibition; Folate pathway; Heck coupling; Staphylococcal aureus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Tetra-Hidrofolato Desidrogenase / Desenho de Fármacos / Inibidores Enzimáticos Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article

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